Class 12 Biology MCQ – Principles of Inheritance and Variation

1. Who is considered the "Father of Genetics"?

a) Charles Darwin
b) Gregor Mendel
c) James Watson
d) Rosalind Franklin

Answer:

b) Gregor Mendel

Explanation:

Gregor Mendel's pioneering work with pea plants laid the groundwork for the field of genetics.

2. Which law states that alleles segregate independently of each other during gamete formation?

a) Law of Dominance
b) Law of Segregation
c) Law of Independent Assortment
d) Law of Variation

Answer:

c) Law of Independent Assortment

Explanation:

This law is based on Mendel's dihybrid cross experiments.

3. Which base pair in DNA is complementary?

a) Adenine-Thymine
b) Cytosine-Guanine
c) Adenine-Guanine
d) Thymine-Cytosine

Answer:

a) Adenine-Thymine

Explanation:

In DNA, Adenine pairs with Thymine, and Cytosine pairs with Guanine.

4. In humans, which chromosome determines the male sex?

a) X chromosome
b) Y chromosome
c) Both X and Y chromosomes
d) Neither X nor Y chromosome

Answer:

b) Y chromosome

Explanation:

Males have an XY chromosomal configuration, with the Y chromosome determining maleness.

5. Which genetic disease is caused by the absence of a functional clotting factor?

a) Hemophilia
b) Sickle cell anemia
c) Down syndrome
d) Phenylketonuria

Answer:

a) Hemophilia

Explanation:

Hemophilia is a genetic disorder where blood does not clot normally due to the absence of a specific clotting factor.

6. Which genetic cross results in a 9:3:3:1 phenotypic ratio?

a) Monohybrid cross
b) Test cross
c) Dihybrid cross
d) Backcross

Answer:

c) Dihybrid cross

Explanation:

A dihybrid cross, studying two traits simultaneously, results in a 9:3:3:1 ratio in the F2 generation.

7. Which term describes the alternative forms of a gene?

a) Allele
b) Genotype
c) Phenotype
d) Chromosome

Answer:

a) Allele

Explanation:

Alleles are the alternative versions of a gene that determine different traits.

8. Which of the following is not a type of mutation?

a) Deletion
b) Inversion
c) Duplication
d) Integration

Answer:

d) Integration

Explanation:

Integration is not a mutation type. Mutations include deletion, inversion, duplication, insertion, etc.

9. A phenotype resulting from the expression of both alleles in a heterozygote is termed:

a) Co-dominance
b) Incomplete dominance
c) Dominance
d) Recessiveness

Answer:

a) Co-dominance

Explanation:

In co-dominance, both alleles are fully expressed in the heterozygote.

10. Which condition results from a trisomy of chromosome 21?

a) Turner syndrome
b) Down syndrome
c) Klinefelter syndrome
d) Edwards syndrome

Answer:

b) Down syndrome

Explanation:

Down syndrome results from three copies (trisomy) of chromosome 21.

11. Which term describes the genetic makeup of an organism?

a) Genotype
b) Phenotype
c) Karyotype
d) Isotype

Answer:

a) Genotype

Explanation:

Genotype refers to the genetic constitution of an organism.

12. Linked genes are located on:

a) Different chromosomes
b) The same chromosome
c) Mitochondria
d) Ribosomes

Answer:

b) The same chromosome

Explanation:

Linked genes are genes located close to each other on the same chromosome and tend to be inherited together.

13. What is the probability of obtaining a recessive phenotype from a heterozygous couple?

a) 25%
b) 50%
c) 75%
d) 100%

Answer:

a) 25%

Explanation:

The possible combinations are AA, Aa, aA, and aa. Only aa shows the recessive phenotype, so the probability is 25%.

14. Which of the following diseases is autosomal dominant?

a) Cystic fibrosis
b) Huntington's disease
c) Hemophilia
d) Tay-Sachs disease

Answer:

b) Huntington's disease

Explanation:

Huntington's disease is caused by a dominant allele.

15. The physical appearance of an organism is its:

a) Genotype
b) Phenotype
c) Allele
d) Genome

Answer:

b) Phenotype

Explanation:

Phenotype refers to the observable physical and physiological traits of an organism.

16. A gene that masks the effect of another gene is termed:

a) Dominant
b) Recessive
c) Epistatic
d) Polygenic

Answer:

c) Epistatic

Explanation:

Epistasis is the masking effect of one gene over another.

17. Variation within a species can be attributed to:

a) Genetic factors only
b) Environmental factors only
c) Both genetic and environmental factors
d) Neither genetic nor environmental factors

Answer:

c) Both genetic and environmental factors

Explanation:

Both genes and environment play a role in causing variations within a species.

18. Which mutation results in a frame shift?

a) Point mutation
b) Deletion
c) Inversion
d) Duplication

Answer:

b) Deletion

Explanation:

Deletions (or insertions) can cause a frame shift, altering the reading frame of the genetic code.

19. Which inheritance pattern shows a blending of phenotypes?

a) Co-dominance
b) Complete dominance
c) Incomplete dominance
d) Polygenic inheritance

Answer:

c) Incomplete dominance

Explanation:

In incomplete dominance, the phenotype of the heterozygote is intermediate between the two homozygotes.

20. Which of the following is not a Mendelian trait?

a) Seed color in peas
b) Flower color in peas
c) Human skin color
d) Stem height in peas

Answer:

c) Human skin color

Explanation:

Human skin color is controlled by multiple genes, making it a polygenic trait, not a simple Mendelian trait.

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